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KMID : 0370220080520030219
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Yakhak Hoeji
2008 Volume.52 No. 3 p.219 ~ p.224
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In Vitro Selection of MRSA Strains Resistance to Some New Fluoroquinolone Antibiotics and Characterization of their Resistance Mechanisms
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Yun Eun-Jeong
Shim Mi-Ja
Choi Eung-Chil
Kim Hyun-Ji
Lee Chun-Yeong
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Abstract
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Clinically isolated methicillin-resistance Staphylococcus aureus strains were exposed to subinhibitory concentration of DW286, DW-224a, gemifloxacin, trovafloxacin, sparfloxacin and ciprofloxacin during 26- to 39-days period. Subculturing led to resistance development, and most of the selected mutants were above susceptible breakpoints. Selected mutants had broad cross resistance to other quinolone antibiotics and only one mutant was completely susceptible to all fluoroquinolones. Twenty five among 42 mutants revealed mutation on DNA gyrase and topoisomerase Ⅳ and action of efflux pumping out system are the resistance mechanism of DW-224a.
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